Regulatory References

General Regulatory Links

United States

Links to FDA email addresses regarding specific regulatory questions

Questions about the UNII

Corrections and questions about the IID

FDA Common Excipient Guidance Documents and Related Pages

Search for FDA Guidance Documents

> Testing of Glycerin, Propylene Glycol, Maltitol Solution, Hydrogenated Starch Hydrolysate, 
    Sorbitol Solution, and Other High-Risk Drug Components for Diethylene Glycol and Ethylene Glycol / FDA

Guidance for Industry Non-Clinical Studies for the Safety Evaluation of Pharmaceutical Excipients

Guidance, Compliance, & Regulatory Information

Providing Regulatory Submissions in Electronic Format — Certain Human Pharmaceutical Product Applications and Related Submissions Using the eCTD Specification

U.S. FDA Drug Master File: Guidelines

FDA Common Excipient Related Web Pages

FDA CDER Inactive Ingredient Search (IID)

Helpful Webinars and Other Resources for Generic Drug Manufacturers - FDA

FDA Inspection Classification Database

FDA Over the Counter Drug Monographs

Food and Drug Administration Reauthorization Act of 2017 (FDARA)

Generic Drug User Fee Amendments of 2017

GRAS

> FDA's Global Substance Registration System

Substance Registration System - Unique Ingredient Identifier (UNII)

> U.S. FDA Drug Master Files (DMFs) Website

U.S. FDA Federal Register Documents, Dockets, and Daily Listings

Europe

EU Falsified Medicines Directive, EMEA Q&A

Annex to the European Commission guideline on "Excipients in the labeling and package leaflet of
   medicinal products for human use" - European Medicines Agency (EMA)

China

National Medical Products Administration (NMPA) English website

Provisions for Supervision of Drug Distribution (SFDA Decree No.26)


Product Regulatory Data Sheet

Regulatory Information Compendia/Regulations

Compendia/Regulations

> British Pharmacopoeia

> Chinese Pharmacopoeia

Certification of Suitability (CEP) - European Directorate for the Quality of Medicines & Healthcare

> EU EudraLex

> European Pharmacopoeia

> Food Chemical Codex

> Japanese Pharmacopoeia 17th Edition

> Japanese Pharmaceutical Excipients (JPE) 2018

> The International Pharmacopoeia

> US 21CFR

> USP/NF

Regulatory Information - BSE/TSE

> European Union

> Japan

> United States

Allergens

> European Union

> United States

Regulatory information – GMOs

> China (English version of the Ministry Of Health site is under construction)

> European Union

> United States

Miscellaneous

European Medicines Agency (EMA)

Quality Guidelines: Impurities / European Medicines Agency (EMA)

Elemental Impurities in Drug Products Guidance for Industry / FDA

• ICHQ3D(R1)

ICHQ3D(R2)

ICHQ3D training

• US FDA

EU EMA overview

Halal:

• IFANCA-Islamic Food and Nutritional Council of America

• Muslim Consumer Group

Kosher:

• Kosher Certification

OU Kosher

Star-K

Other:

National Organic Standards Board

California Proposition 65

Residual Solvents - ICH Q3C:

ICHQ3C(R8)

US FDA Version

EMEA Version


Site Quality Overview

IPEC Excipient GMP Related Guidance Documents (Guides are available in the Public Library; sign in to gain access.)

Compliance evidence

Your Food Safety Global Partners - AIB International, Inc.

Pharmaceutical Excipients Auditing

EXCiPACT

ISO International Organization for Standardization

IPEC GMP compliance details

> IPEC-PQG GMP Audit Guide for Pharmaceutical Excipients

Miscellaneous site information

> HACCP - Hazard Analysis & Critical Control Points

> Statistical Process Control/Process Analytical Technology (PAT) – Guidance


Site and Supply Chain Security Overview 

Site and supply chain security

> Bio-Terrorism Act

> CFATS Chemical Facility Anti-Terrorism Standards

> C-TPAT (Customs - Trade Partnership Against Terrorism) 

> Rx-360

Safety and environmental information

> ACC Responsible Care

> ISO 14000

> ISO Standards